Laura Grabel
Campus Extension: 3238
Neurogenesis of embryonic stem cells, fate of embryonic stem cell-derived transplants in the brain, and cell migration in the early embryo. Links
Grabel Lab Home Page
Our laboratory uses in vitro model systems to study various aspects of mammalian development. Migration of primitive (parietal) endoderm This project uses F9 teratocarcinoma and embryonic stem cell embryoid bodies to identify molecular signals regulating the first migratory event in the mammalian embryo. Recent work focuses on the non-canonical Wnt (planar cell polarity) pathway. Making neural stem cells from embryonic stem cells Based on their therapeutic potential, there is great interest in producing neural stem cells, as well as neurons and glia, from embryonic stem cells. Current studies are examining how the Hedgehog pathway promotes embryonic stem cell neurogenesis. Fate of embryonic stem cell-derived neural stem cells transplanted to the hippocampus using a mouse model of temporal lobe epilepsy (These studies are performed in collaboration with Janice Naegele, http://www.wesleyan.edu/bio/naegele/naegele.html, and Gloster Aaron, http://www.wesleyan.edu/bio/Aaron/aaron.html, in Wesleyan's Biology Department) Funding: NIH and the Connecticut Stem Cell Initiative |
Lauren
B. Dachs Professor of Science in Society