Over the last two decades advances in modern molecular genetics has provided insights into the underlying genetic basis for many of humankind’s inherited disorders.  The information associated with the sequencing of the human genome combined with sophisticated gene mapping strategies is yielding an increasing number of genetic variations (mutations) that are associated with specific human diseases.  This course will cover these advances, and how they relate to dominant, recessive, and sex-linked mutations, single gene disorders such as cystic fibrosis and Huntington’s disease, as well as multi-factorial disorders including cancer, heart disease and diabetes.   We will also consider how advances in genetic testing and screening can apply to early diagnosis and the prospect of individualized medicine.   Furthermore, we will discuss how specific mutations vary between sub-populations, and impact that these variations have on the interactions between individuals and their environment.  Students will be expected to research one of these topics in depth, and to give an in-class presentation as well as submit a paper. A background in basic molecular biology (equivalent to introductory college level biology) is recommended.  Readings will include review articles, primary scientific literature and chapters form texts on the different diseases.

Video: A Question of Genes