Biology of Aging
"People in the U.S. are living longer than ever before. Many seniors live active and healthy lives. But there's no getting around one thing: as we age, our bodies and minds change" (from Medline, Seniors' Health). This course will consider 4 important questions: What are the changes to body and mind that take place during aging? What are the causes of the major diseases that afflict the elderly and what research avenues point to prospects for treatment? What research is being done to explore the underlying basis of the aging process? What are the prospects for intervention in the aging process, thereby extending lifespan?
Each class meeting will be divided into two parts. One part will be a lecture providing a conceptual introduction to a specific topic (shown below in bold). The second part will involve a student-led class discussion of a recent review article on the subject introduced by a lecture. One day (or more) is scheduled between the introduction, and the student presentation on that topic. This is to give students time to make use of the information introduced in lecture to provide increased comprehension while reading the review article, and it also allows us to build on a subject over a two day period of time.
|Lectures and Discussions|
|Introduction to Aging and the Elderly; Our aging society: measuring lifespan; centenarians; how to study aging; senescence.||Cellular senescence; regulated cell death (apoptosis and autophagy)|
|Diabetes||Cell Senescence and Cell Death
Vicencio et al (2008)
Miller & Adeli (2008)
Small & Duff (2008)
Sano et al (2008)
Shibata & Glass (2008)
|Caloric restriction and model systems||Cancer
DePinho RA (2000)
Hsu & Sabatini (2008)
|Genetic diseases of premature aging||Caloric restriction
Kennedy et al (2008)
|Free radicals, oxidative damage and aging||Progeria
Martin et al (2008
Wang & Sun (2008)
|Stem cell biology and aging||Free radicals
Willcox et al (2008)
Lesnefsky & Hoppel (2008)
|An evolutionary perspective on aging||Stem cells
Yunis et al (2006)
Warren & Rossi (2008)
Our aging society; changing life spans;
centenarians; how to study aging
|Resources for Class Discussion|
Bronwen M, Golden E, Carlson OD, Egan JM, Mattson MP, & Mauldsley S, (2008) Ageing Research Reviews 7:209–224.Caloric restriction: Impact upon pituitary function and reproduction.
Campisi J, (2008) Aging Cell 7:281-284
DePinho RA, (2000) Nature 408:248-254
Fröjdö S, Vidal H &Pirol L, (2008) BBA in press
Gallagher JC, (2008) Maturitas 60:65-69
Gazit R, Weissman IL & Rossi DJ, (2008) Seminars in
Hematology 45:218 - 224 R
Guarente L, (2007) Cold Spring Harbor SQB 72:483-8.
Hsu PP & Sabatini DM (2008) Cell 134:703-7
Jackson RD & Shidham S, (2007) Curr Osteoporos Rep.
Kennedy BK, Steffen KK & Kaeberlein M, (2007) Cell.
Mol. Life Sci. 64:1323–1328.
Lesnefsky EJ & Hoppel CL (2006) Ageing Research Reviews
Marquess JG, (2008) Consult Pharm. Suppl B:5-11
McBride H, (2008) J Cell Biol 183:757-759
Miller A & Adeli K, (2008) Current Opinion in
Nicholls SJ, (2008) Curr Opin Investig Drugs. 9:950-6
Sano M, Grossman H & Van Dyk K, (2008) CNS Drugs
Shibata N & Glass CK, (2008) J. Lipid Res. in press
Small SA & Duff K, (2008) Neuron 60:534-42
Vicencio JM et al, (2008) Gerontology 54:92-99
Wang Y & Sun L (2008) Ageing Research Reviews in press.
Bradley J. Willcox BJ , Curb JD & Rodriguez BL (2008)
The American Journal of Cardiology, 10:Supplement 1, S75-S86
Yunis EY, Zúñiga J, Koka PS, Husain Z, Romero V, Stern
JNH, and Masha Fridkis-Harel MF, (2006) J Stem Cells 1:125–147.