MolBioPhys

Graduates Supported By NIH Traineeships

2001- present

Kristi (Wojtuszewski) Poulin
Eliana Tsurkoff
Jerome Shiels
Kelly Thayer
Jacob Tuite
Kelly Knee
Alicia Every
Laure H. Dykas
Andrew T. Moreno

Nota bene: This represents only a fraction of the total scientific activity of our program, since only US Citizens are eligible for NIH support and we only have three slots per year available for them. For a complete list of students mentored by participating faculty, see the entries under "Faculty" on this website. 

(in chronological order, 2001 - present):

Kristi (Wojtuszewski) Poulin 
(B.A. East Stroudsberg, 1990; M.S. University of Scranton, 1993) MBTG Yr. 10.

  • Dissertation Project: "DNA Binding with HU" (Prof. I. Mukerji, mentor)
  • Professional Activities: Poster presentation at 1999 Biophysics meeting.
  • Graduated with PhD in Molecular Biology and Biochemistry, May 2002.
  • Publications Based on Dissertation Research:
  1.  
    1.  "Nucleic Acid Structure Investigated by UV Resonance Raman Spectroscopy: Protonation Effects and A-Tract Structure" L. Sokolov, K. Wojtuszewski, E. Tsurkoff, I. Mukerji. J. Biomolec. Struct. Dyn. (2000). 
    2. "HU Binding to DNA: Evidence for Multiple Compelxes and DNA Bending" K. Wojtuszewski, M.E. Hawkins, J.L. Cole, I Mukerji. Biochemistry 40, 2588-259 (2001).

 

Eliana Tsukroff 
(B.S. Central Connecticut State University, 1998) MBTG Yrs. 11, 12, 13, 14.

  • Dissertation Project: "UV REsonance Raman Investigation of pH Titratable Groups on the dGMP Nucleotide" (Prof. I. Mukerji, mentor)
  • Publications Based on Dissertation Research:
  1.  
    1. "Nucleic Acid Structure Investigated by UV Resonance Raman Spectroscopy: Protonation Effects and A-Tract Structure" L. Sokolov, K. Wojtuszewski, E. Tsukroff, I. Mukerji. J. Biomolec. Struct. Dyn. 11(2), 327-334 (2000).

 

Jerome Shiels 
(B.S. University of Massachusetts, 1989) MBTG Yrs. 11, 12.

  • Dissertation Project: "An Investigaton of Energetics in RNA: Protein Interactions" (Prof. A. Baranger, mentor).
  • Graduated with PhD in Chemistry, May 2004.
  • Current Placement: Postodoctoral Fellow, University of Washington
  • Publications Based on Dissertation Research:
  1.  
    1. "Recognition of an Essential Adenine at a Protein: RNA Interface: Comparison of the Contributions of Hydrogen Bonding and Stacking Interactions" S.J. Nolan, J.C. Shiels, J.B. Tuite, K.L. Cecere, A.M. Baranger. J. Am. Chem. Soc. 121, 8951-8952 (1999.)
    2. "RNA-DNA Hybrids Containing Damaged DNA are Substrates for RNase H" J.C. Shiels, B. Jerkovic, A.M. Baranger, P.H. Bolton. Bioorg. Med. Chem. Lett. 11, 2623 (2001).
    3. "Investigation of a Conserved Stacking Interaction in Target Site Recognition by the U1A Protein: J.C. Shiels, J.B. Tuite, S.J. Nolan, A.M. Baranger. Nucleic Acids Res. 30, 550-558 (2002).
    4. "Substitution of an Essential Adenine in the U1A-RNA Complex with Non-polar Isostere" J.B. Tuite, J.C. Shiels, A.M. Baranger. Nucleic Acids Res.13, 2647-2659 (2002).

 

Kelly Thayer 
(B.A. Regis College, 1999) MBTG Yrs. 13, 14.

  • Dissertation Project: "Structural Bioinformatics and Molecular Dynamics of DNA Sequences" (Prof. D.L. Beveridge, mentor).
  • Graduate with PhD in Molecular Biology and Biochemistry, May 2004.
  • Publications Based on Dissertation Research:
  1.  
    1. "Measures and Analyses of DNA Bending" D.L. Beveridge, K.M. Thayer.Biopolymers: Nucleic Acid Sciences (2001).
    2. "Boltzmann Structural Bioinformatics: Hidden Markov Models for CAP-DNA Binding Sites from Molecular Dynamics Simulations" K.M. Thayer, D.L. Beveridge. Proc. Natl. Acad. Sci. (2002).

 

Jacob Tuite 
(B.S. Fairfield University, 1997) MBTG Yrs. 13, 14.

  • Dissertation Project: "Investigation of the RNA-Protein Interactions in the U1A-U1snRNA Complex" (Prof. A. Baranger, mentor)
  • Publications Based on Dissertation Research:
  1.  
    1. "Investigation of a Conserved Stacking Interaction in Target Site Recognition by the U1A Protein" J.C. Shiels, J.B. Tuite, S.J. Nolan, A.M. Baranger. Nucleic Acids Res.30, 550-558 (2002).
    2. "Substitution of an Essential Adenine in the U1A-RNA Complex with Non-polar Isostere" J.B. Tuite, J.S. Shiels, A.M. Baranger. Nucleic Acids Res. (2002).
    3. "Contribution of Hydrogen Bonds Formed with an Essential Adenine t the Stability of the U1A-RNA Complex: Improved Stacking Interactions Can Compensate for the Elimination of Hydrogen Bonds" J.B. Tuite, J.C. Shiels, A.M. Baranger. Biochemistry(2002).

 

Kelly Knee 
(B.A. Alfred University, 2000) MBTG Yrs. 15, 16, 17, 18, 19.

  • Dissertation Project: "UV Resonance Raman Characterization of Sickle Cell Hemoglobin Polymerization" (Prof. I. Mukerji, mentor)
  • Professional Activities: Poster Presentations: "Structural and Energetic Analysis of the DNA A-B Transition Using Spectroscopic and Computational Methods", Thirteenth Conversation on Biomolecular Stereodynamics, June 2003, Albany NY; "Structural Analysis of the DNA B-A Transition", Biophysical Society Meeting, February 2004, Baltimore MD; "Characterization of B-93 Cys Modified Sickle Cell Hemoglobin: A Kinetic and Spectroscopic Study", Biophysical Society Meeting, February 2004, Baltimore, MD; "Spectroscopic and Molecular Dynamics Evidence for a Sequential Mechanism for the DNA B to A Transition", Biophysical Society Meeting, February 2005, Long Beach CA; "Spectroscopic and Molecular Dynamics Evidence for a Sequential Mechanism for the DNA B to A Transition", Fourteenth Conversation on Biomolecular Stereodynamics, June 2005, Albany NY. Talks: "Spectroscopic and Molecular Dynamics Evidence for a Sequential Mechanism for the DNA B to A Transition", Gibbs Thermodynamics Society Meeting, October 2004, Carbondale IL; "Characterization of B-93 Cys Modified Sickle Cell Hemoglobin, October 2004, Wesleyan University Seminar Series, Middletown CT.
  • Graduated with PhD in Molecular Biology and Biochemistry, May 2007.
  • Publications Based on Dissertation Research: "The role of the B93 Cys in inhibition of Sickle Cell Hemoglobin Polymerization"

 

Alicia Every 
(B.S. Union College, 2002) MBTG Yrs. 16, 17, 18, 19, 20.

  • Dissertation Project: "Dynamics and Energetics of DNA Structures and Interactions Studied by Nuclear Magnetic Resonance Spectroscopy" (Prof. I.M. Russu, mentor)
  • Professional Activities: Poster Presentations: "Effects of Magnesium Ions on the Dynamics of Double-Helical DNA", Biophysical Meeting 2004; "Characterization of Hydrogen Bonds in Double-Helical DNA Using H/D Franctionation Factors and Probing the Interaction of Magnesium Ions with Double-Helical DNA by Proton Exchange and Nuclear Magnetic Resonance Spectroscopy, Albany Meeting 2005.
  • Publications Based on Dissertation Research:
  1.  
    1. "Effects of magnesium ions on the dynamics of double-helical DNA", A. Every, D. Coman, I.M. Russu. Biophysical Journal 86, 140A (2004).

Laure H. Dykas 
(B.S. Central Connecticut STate University, 2000) MBTG Yrs. 17, 18, 19, 20

  • Dissertation Project: "Interactions of the Sex-Lethal Protein with the Transformer pre-mRNA (Prof. A.M. Baranger, mentor)
  • Professional Activities: Poster Presentations Yale University Chemical Biology Symposium 2002, 2003 and 2004.
  • Publications Based on Dissertation Research: None yet.

 

Andrew T. Moreno 
(B.S. Eastern Connecticut State University, 2002) MBTG Yrs. 20

  • Dissertation Project: No title yet (Prof. J.L. Knee, mentor)
  • Professional Activities: To be added
  • Publications Based on Dissertation Research: None yet.

 

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