Spring 2004

SCIE 680
The Science of Human Health: Microbiology and Immunology

Oliver,Donald B.

01/26/2004 - 05/08/2004
Wednesday 06:00 PM - 08:30 PM

Shanklin 201

Studying the molecular and cellular biology of disease-causing and bacteria, we will survey the basic mechanisms that they deploy to colonize and harm our bodies. We will also learn about the cells and macromolecules that comprise our immune system, how they act in concert to detect and combat disease, or in certain instances, cause autoimmune disease. A case study approach will be pursued to join these two subjects and illustrate the complex interplay between pathogens and the immune system that allows us to successfully combat certain diseases, become persistently infected by others, or succumb to debilitating or fatal illnesses.

Reading assignments include Sompayrac, HOW THE IMMUNE SYSTEM WORKS; several chapters from Madigan, Martinko, and Parker, BROCK BIOLOGY OF MICROORGANISMS; and selected articles from appropriate journals.

Course requirements include a take-home midterm and a written final paper that will be presented orally.

No previous background in microbiology or immunology is assumed, but knowledge of common biological vocabulary is needed.

Note: Students who have taken SCIE 680: Humankind in Sickness and in Health may not take this course for credit.

A syllabus for this course is available at:
Course Syllabus

Donald Oliver (B.S. Brandeis University; Ph.D. Tufts University) is professor and chair of molecular biology and biochemistry at Wesleyan University. Written in collaboration with Nobel Laureate Hans Deisenhofer's research group, Oliver's research on the crystal structure of SecA protein was published recently in Science Magazine, and his study may help scientists design sorely needed, new, antibacterial drugs.


Consent of Instructor Required: No

Format: Seminar

Level: GLSP Credits: 3 Enrollment Limit: 18

Texts to purchase for this course:
Madigan, Martinko, and Parker, BROCK BIOLOGY OF MICROORGANISMS, 10th edition (Prentice Hall) hardcover

Lauren Sompayrac, HOW THE IMMUNE SYSTEM WORKS (Blackwell Science) Paperback


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