Fall 2006

SCIE 681
The Genetic Basis of Inherited Disorders

McAlear,Michael A.

09/11/2006 - 12/16/2006
Tuesday 06:00 PM - 08:30 PM

Shanklin 201

Over the last two decades, advances in modern molecular genetics have provided insights into the underlying genetic basis for many of humankind's inherited disorders. The information associated with the sequencing of the human genome, combined with sophisticated gene mapping strategies, is yielding an increasing number of genetic variations (mutations) that are associated with specific human diseases. This course will cover these advances, and how they relate to dominant, recessive, and sex-linked mutations, single gene disorders such as cystic fibrosis and Huntington's disease, as well as multi-factorial disorders including cancer, heart disease, and diabetes. We will also consider how advances in genetic testing and screening can apply to early diagnosis and the prospect of individualized medicine. Furthermore, we will discuss how specific mutations vary between sub-populations, and the impact that these variations have on the interactions between individuals and their environment.

Readings will include review articles, primary scientific literature, and chapters from texts on the different diseases.

Students will be expected to research one of these topics in depth, and to give an in-class presentation as well as submit a paper.

A background in basic molecular biology (equivalent to introductory college level biology) is recommended

A syllabus for this course is available at:
http://www.wesleyan.edu/masters/courses/Fall_2006/Course%20Syllabi/syb_scie681.html


Michael McAlear (B.S., Ph.D. McGill University) is associate professor of molecular biology and biochemistry. His research focuses on DNA replication, DNA repair, and rRNA metabolism in yeast, and his articles have appeared in the journals Biochemistry, Molecular and Cellular Biology, Genetics, Molecular Genetics, and the Journal of Biological Chemistry. Click here for more information about Michael McAlear.


ENROLLMENT INFORMATION

Consent of Instructor Required: No

Format: Seminar

Level: GLSP Credits: 3 Enrollment Limit: 18

Texts to purchase for this course:
THE INSTRUCTOR HAS NOT YET ORDERED TEXTS FOR THIS COURSE.

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