DeSimone Jr,Robert W.
01/23/2006 - 05/06/2006
Monday 06:00 PM - 08:30 PM
With the advent progress in molecular biology techniques for isolation and identification of receptors--the molecular target where drugs induce a biological function--a vast array of new molecular targets have been discovered over the last 10 years. Coupled with the advances in High Throughput Screening (HTS) and Parallel Synthesis the pharmaceutical industry today has the unique ability to discover and develop medications to treat a vast array of diseases. We will examine the current approach the pharmaceutical industry is employing to discover new drugs, compared with the traditional approach, by evaluation of the following therapeutic areas: hypertension, cancer, anxiety and depression. We will also explore the mechanism of action of a number of marketed drugs, such as Prozac, Prilosec, and Claritin as well as new medications that are on the horizon.
The text for the course is Thomas Nogrady Medicinal Chemistry: A Biochemical Approach.
Evaluation is based on the understanding of concepts discussed in class and the ability to apply them in the context of class discussions, an exam and group projects.
Students are expected to have had an introductory level college biology or chemistry course.
A syllabus for this course is available at:
Robert DeSimone (B.S. Marist College; M.S. Fairleigh Dickinson University; Ph.D. Wesleyan University) is president/founder of Privileged Discovery Partners LLC, a seed stage biotechnology company, and former Senior Director of Chemistry at Cellular Genomics. He has filed more than 50 patents in drug discovery and is primary or contributing author of more than 20 articles and presentations in the field of drug discovery.
Consent of Instructor Required: No
|Level: GLSP||Credits: 3||Enrollment Limit: 18|
Texts to purchase for this course:
Thomas Nogrady, MEDICINAL CHEMISTRY: A MOLECULAR AND BIOCHEMICAL APPROACH (Oxford University Press) 3rd Edition, Paperback
READING MATERIALS AVAILABLE AT BROAD STREET BOOKS, 45 BROAD STREET, MIDDLETOWN, 860-685-7323
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