Neuroscience & Behavior Program

Faculty & Office Hours

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	Naegele, Janice R. Professor of Biology Biology Department 860.685.3232 Hall-Atwater Laboratories 254 Professor, Neuroscience & Behavior Neuroscience and Behavior Program 860.685.3232 BA Mount Holyoke College PHD Massachusetts Institute of Technology
EMAIL:	jnaegele@wesleyan.edu
PERSONAL HOME PAGE:	http://www.wesleyan.edu/bio/naegele/naegele.html
WESLEYAN PO BOX:	Biology Department
COURSES TAUGHT THIS SEMESTER:	BIOL591 - 08
RESEARCH INTERESTS:	Naegele Lab Research Our research interests focus neurogenesis and cell death during embryonic brain development and in the adult hippocampus. We study the cellular and molecular basis for neurogenesis and cell death using a combination of in vitro and in vivo approaches including: primary cell cultures, in utero gene transfection studies in embryos, RNA interference, and genetic knockout mice. Our work focuses on the role of KU70 and pro-apoptotic genes including: caspases, Bax, and p53. In addition to studies at embryonic times of development, we also investigate neurogenesis and cell death in the adult mouse hippocampus and the efficacy of ES-derived neural stem cell grafts for repairing seizure induced damage and controlling seizures in mouse models of temporal lobe epilepsy
AREAS OF EXPERTISE:	Epilepsy Adult neurogenesis GABA Hippocampus Neural stem cells Embryonic stem cells Excitoxicity Apoptosis Neuroprotection DNA Repair Ku70 Bax
ACADEMIC ASSOCIATIONS:	Society for Neuroscience AAAS American Epilepsy Society Women in Neuroscience Connecticut Chapter of the Society for Neuroscience
AWARDS WON:	McKnight Foundation Brain Disorders Award 2007-2010.
OFFICE HOURS:	Fall 2009 Sabbatical By appointment only
PUBLICATIONS:	http://www.wesleyan.edu/bio/naegele/naegepub.html
GRANTS:	The McKnight Foundation The Fragile X Foundation Connecticut Stem Cell Initiative