SCIE 680
The Molecular Biology of Emerging Infectious Diseases
Michael McAlear
| Course Schedule | |||||||||||||
| January 23 |
Introduction, Basic Molecular & Cellular Biology Germ theory, Koch's postulates |
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| January 30 | Bacteria and Antibiotics | ||||||||||||
| February 6 | Antibiotic Resistance | ||||||||||||
| February 13 | Anthrax | ||||||||||||
| February 20 |
Viruses, Ebola Reading: "The Hot Zone" |
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| February 27 | West Nile virus | ||||||||||||
| March 6 | Class Test I | ||||||||||||
| March 13 | Spring Break: No Class | ||||||||||||
| March 20 | Spring Break: No Class | ||||||||||||
| March 27 |
The Flu Virus The Polymerase Chain Reaction: Part I |
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| April 3 |
Parasites, Malaria PCR: Part II |
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| April 10 | Prions, Creutzfeldt-Jakob disease | ||||||||||||
| April 17 | Mad Cow Disease | ||||||||||||
| April 24 | Class Test II | ||||||||||||
| Course Description | |||||||||||||
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Whereas only a few decades ago it seemed that modern medicine was well on its way to dealing with many of the bacterial and vial diseases that afflicted mankind, recently we have seen the emergence, and re-emergence of a host of deadly, infectious pathogens. This course will focus on a subset of these diseases, including antibiotic-resistant bacteria, mad cow disease, West Nile virus, anthrax and Ebola. The majority of the course will deal with how these infectious agents work at the molecular level, and how they can be treated (if at all). We will also consider how changes in populations, social practices, and environments have contributed to their emergence. Students will be expected to research one of these topics in depth, and to give an in-class presentation as well as submit a paper. Students will also get the opportunity to learn and perform a modern diagnostic technique (PCR) that is used to identify infectious agents. A background in basic molecular biology (equivalent to introductory college level biology) will be assumed knowledge. Readings will include review articles, primary scientific literature and books on the different diseases. |
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| Grading | |||||||||||||
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| Texts | |||||||||||||
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The Coming Plague, L. Garrett Epidemic!, R. DeSalle The Hot Zone, R. Preston |
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